Bexarotene has been approved for the treatment of cancer by the U.S. Food and Drug Administration for more than a decade. These experiments explored whether the medication might also be used to help patients with Alzheimer's disease, and the results were more than promising.
In particular, the researchers were struck by the speed with which bexarotene improved memory deficits and behavior even as it also acted to reverse the pathology of Alzheimer's disease. The present view of the scientific community is that small soluble forms of amyloid beta cause the memory impairments seen in animal models and humans with the disease. Within six hours of administering bexarotene, however, soluble amyloid levels fell by 25 percent; even more impressive, the effect lasted as long as three days. Finally, this shift was correlated with rapid improvement in a broad range of behaviors in three different mouse models of Alzheimer's.
Dr. Kade Goepferd watched the Trump administration's moves on Thursday to ban gender-affirming care for transgender...
A California jury on Friday awarded $40m to two women who said Johnson & Johnson’s baby...
With subsidies for Affordable Care Act (ACA) health insurance set to expire, Americans who rely on...
Connecticut, Georgia, Idaho, Massachusetts, Michigan, Rhode Island, South Carolina, Texas and Puerto Rico also saw an...
