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A single infusion of an experimental gene-editing drug appears safe and effective for cutting cholesterol, possibly for life, according to a small early study released Saturday.

The study, which involved 15 volunteers, found one infusion of a drug that uses the CRISPR gene-editing technique could safely reduce cholesterol, as well as levels of harmful triglycerides, by about half.

"Rather than a lifetime worth of medicine, we have the potential to give people a cure," said Dr. Luke Laffin, a preventative cardiologist at the Cleveland Clinic who helped conduct the study. "It's very exciting."

The results of the study were presented Saturday at the American Heart Association's annual meeting and published in The New England Journal of Medicine.

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Cancer continues to be one of the world's top causes of death, due in part to delayed discovery of the disease. But according to a recently released study, a simple blood test may be able to identify a variety of cancers in their early stages.

In addition to earlier detection, the study from GRAIL, a biotechnology company, showed that its multi-cancer early detection (MCED) testing method found cancers in organs that don't have routine screening tests. The test, known as Galleri, picked up cancer signals in 216 people, and 133 of them were found to actually have cancer. The study also found that the test correctly predicted the cancer's origin 92% of the time.

Shifting cancer screening options

Because of the lack of screening for many of the most serious cancers, they tend to be found after it is too late. But when tumors are found early on, they are more treatable and possibly curable.

There are currently established screening methods for various cancers, including mammograms, pap tests, colonoscopies, and tests for the prostate and lungs.

The FDA has not yet approved the Galleri MCED testing method; more research is currently ongoing.

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A deadly listeria outbreak connected to prepared pasta meals sold at grocery chains nationwide is worsening, federal health officials say.

As of late October, the outbreak has killed six people and sickened 27, all but two of whom were hospitalized, according to last week's update from the Centers for Disease Control and Prevention (CDC). One of those affected was a pregnant mother, resulting in a fetal loss.

Cases have been reported in 18 states: California, Florida, Hawaii, Illinois, Indiana, Louisiana, Michigan, Minnesota, Missouri, North Carolina, Nevada, Ohio, Oregon, South Carolina, Texas, Utah, Virginia and Washington.

"Since the last CDC case count update on September 25, 2025, a total of 7 new illnesses from 3 states have been reported, with 2 additional deaths reported," the Food and Drug Administration (FDA) said.

That list has grown in recent months. The outbreak started in June, when listeria concerns prompted recalls of several brands of ready-to-eat chicken fettuccine Alfredo mealsmade by FreshRealm Inc. and sold under the Home Chef brand at Kroger and the Marketside brand at Walmart.

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A common solution to sleeplessness may have adverse health effects.

Consistently taking melatonin supplements, which are commonly used to promote sleep and address insomnia, was associated with a higher risk of heart failure diagnosis, heart failure hospitalization and death from any cause in chronic insomnia, according to a preliminary study that will be presented at the American Heart Association’s Scientific Sessions in November.

Among more than 100,000 adults diagnosed with insomnia, those with consistent melatonin use had a 90% higher chance of incident heart failure over five years compared with non-users. Melatonin users were nearly 3 1/2 times as likely to be hospitalized for heart failure compared to those not taking the supplement. The study cautions there isn't yet a direct connection between melatonin and heart disease.

But “,elatonin supplements may not be as harmless as commonly assumed. If our study is confirmed, this could affect how doctors counsel patients about sleep aids,” said Ekenedilichukwu Nnadi, lead author of the study and chief resident in internal medicine at SUNY Downstate/Kings County Primary Care in Brooklyn, New York.

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One of the monkeys that escaped after a truck overturned on a Mississippi roadway on 28 October was shot and killed early Sunday by a homeowner who said she feared for the safety of her children.

Jessica Bond Ferguson said she was alerted early Sunday by her 16-year-old son who said he thought he had seen a monkey running in the yard outside their home near Heidelberg, Mississippi. She got out of bed, grabbed her firearm and her cellphone, and stepped outside where she saw the monkey about 60 ft (18 meters) away.

Bond said she and other residents had been warned that the escaped monkeys were potentially diseased, so she fired her gun.

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“I did what any other mother would do to protect her children,” Bond, who has five children ranging in age from four to 16, told the Associated Press. “I shot at it and it just stood there, and I shot again, and he backed up and that’s when he fell.”

The Jasper county sheriff’s office confirmed in a social media post that a homeowner had found one of the monkeys on their property Sunday morning but said the office didn’t have any details. The Mississippi department of wildlife, Fisheries, and parks took possession of the monkey, the sheriff’s office said.

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A civil jury in Maine has awarded $25m to a woman whose teenage daughter died from leukemia after being misdiagnosed with a condition linked to steroid-using men.

The hefty verdict delivered in favor of Lyndsey Sutherland on Thursday called for her to receive $10m for the wrongful 2021 death of 15-year-old Jasmine “Jazzy” Vincent as well as $15m for pain and suffering, said her attorney, Meryl Poulin.

Poulin said on Friday that the verdict could be appealed, and an applicable Maine state law caps wrongful death damages at $750,000. Nonetheless, Poulin said, she hoped the amount awarded to her client sends “a clear message that Maine juries are willing to hold medical providers accountable when they fail to meet minimum standards of care”.

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