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Tuesday, Mar 19th

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White House’s Paxlovid push hits hurdles

Paxlovid

The Biden administration has gone all in on the COVID-19 antiviral Paxlovid, announcing new measures to make the oral treatment more widely available and making it clear that Vice President Harris used it as she recovered from the coronavirus.

The White House has said it will nearly double the amount of Paxlovid available around the country and that it is working to set up more Test-to-Treat locations in pharmacies and other locations.

But the administration faces a number of obstacles in really making Paxlovid, and a similar treatment from Merck and Ridgeback known as molnupiravir, easily accessible to Americans.

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New Omicron Subvariants Take Hold As Biden Wants Americans To Learn To Live With COVID

New variants surge as masks come off.A new omicron subvariant, BA.2.12.1, is taking hold in the U.S. and was the second-most widely spread form of the coronavirus last week, according to a report published Tuesday by the Centers for Disease Control and Prevention.

BA.2.12.1 made up 19% of total U.S. cases the week ending April 16, increasing its spread by almost 67% from the week before. The CDC says omicron variants overall cause less-severe illness, although they spread faster than previous variants like delta.

Mutations in COVID variants are allowing the virus to dodge protection offered by vaccines in some cases, Andy Pekosz, a professor at the Johns Hopkins Bloomberg School of Public Health, told CNN.

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Even a mild case of COVID-19 can cause brain changes. It's too soon to know if the damage lasts.

brain changes caused by Covid-19

A new study provides the most conclusive evidence yet that COVID-19 can damage the brain, even in people who weren't severely ill.

The study, published Monday in Nature, used before-and-after brain images of 785 British people, ages 51 to 81, to look for any changes. About half the participants contracted COVID-19 between the scans – mostly when the alpha variant was circulating – which left many people at least temporarily without a sense of smell.

Analysis of the "before" and "after" images from the UK Biobank showed that people infected with COVID-19 had a greater reduction in their brain volumes overall and performed worse on cognitive tests than those who had not been infected.

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CDC updates guidance for intervals between COVID-19 vaccine doses

CDC changes interval between vaccinesThe Centers for Disease Control and Prevention (CDC) on Tuesday issued new COVID-19 mRNA vaccine guidance, expanding the recommended time between the initial two vaccine doses to eight weeks for some people over the age of 12, particularly young men.

The prior recommended interval between initial doses was three weeks for the Pfizer-BioNTech vaccine and four weeks for the Moderna vaccine. This timeline is still recommended by the CDC for individuals who are immunocompromised, over 65 years old or in need of rapid protection against the coronavirus.

According to the CDC, however, leaving more time between the first two doses of mRNA COVID-19 vaccines may reduce the risk for severe side effects such as myocarditis, or inflammation of the heart wall.

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Amid backlash from chronic pain sufferers, CDC drops hard thresholds from opioid guidance

CDC opioid limits changedNew guidance on prescribing opioids unveiled Thursday by the Centers for Disease Control and Prevention avoids the strict limits found in a 2016 version that accelerated a nationwide drop in pain pill prescriptions but led to backlash from chronic pain patients.

The 229-page document advises doctors to limit new opioid prescriptions and discuss alternative therapies with patients. But the new guidance largely avoids figures on dosage and length of prescription and warns against abruptly or rapidly discontinuing pain pills for some chronic pain patients.

"We've built in flexibility so that there's not a one-size-fits-all approach," said Christopher Jones, acting director of the CDC's National Center for Injury Prevention and Control.

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FDA approves first injectable drug to prevent HIV

FDA approves HIV prevention drugA new injectable treatment for HIV pre-exposure prevention, or PrEP, has been approved by the Federal Drug Administration.

The drug, Apretude, is approved for at-risk adults and adolescents who weigh at least 77 pounds to reduce the risk of sexually acquired HIV, the FDA announced Monday.

“Today’s approval adds an important tool in the effort to end the HIV epidemic by providing the first option to prevent HIV that does not involve taking a daily pill,” Debra Birnkrant, director of the Division of Antivirals in the FDA’s Center for Drug Evaluation and Research, said in the announcement.

After the initial two injections, Apretude is administered one month apart, then every two months after that. The hope is that high-risk individuals, like men who have sex with men, will have better adherence to taking the PrEP injectable option every two months versus taking a pill everyday.

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Harvard announces January move to remote learning, work as COVID-19 case numbers rise

Harvard goes remoteHarvard University announced on Saturday that it would be transitioning to remote learning for several weeks in January amid an increase of new cases in the area and around the country.

In a letter to the school’s community, Harvard officials said that for the first three weeks of January, “we will take steps to reduce density on campus by moving much of our learning and work remotely."

The letter noted that students who had received approval from their specific school or previous authorization would be the only students allowed to remain on or return to campus during the three-week period.

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